… neuralgia, temporomandibular joint disorders, migraine and … found that inflammatory orofacial
allodynia in rats was related … NK1 receptors are expressed in both neurons and SGCs, so …

… effector systems underlying neurokinin 1 receptors (NK1Rs) in … in rodents produced chronic
and bilateral mechanical … sensory neurons in an autocrine or paracrine manner. In the PNS…

… mice exhibit a thermal response similar to wild-type mice [100]. … from the facial skin and
temporomandibular joint [105,129,130]… mRNAs for substance P and its receptor neurokinin-1 has …

… of neurokinin-1 (NK1) receptors, receptors for substance P, has indirectly been shown by
functional studies in the rat trigeminal ganglion. … temporomandibular joint and facial skin was …

… pain encompasses dental pain, temporomandibular joint (… A mice experiment demonstrated
that CGRP upregulated … C; SP, substance P; TRPM3, transient receptor potential cation …

… allodynia of the inflamed temporomandibular joint (TMJ) in … in an inflammatory soup-induced
trigeminal allodynia in a rat … upregulates TrkB through a paracrine/autocrine mechanism, …

… hybridization (ISH) in rats after rat upper molar extraction. We … from the temporomandibular
joint (TMJ) inflammation by using … that, under TMJ inflammation, substance P (SP) released …

… and NK1 receptors in Vc and C1-C2 nociceptive neurons. Further, … a paracrine mechanism
via substance P (SP)-neurokinin 1(… activity in rats with persistent temporomandibular joint and …

… shown to contribute to orofacial neuropathic pian via CXCR5/… via activation of p38 MAPK in
the trigeminal ganglion of mice [… site of injury and the dorsal root ganglion (DRG) that induces …

… Furthermore, substance P receptor antagonists have failed in … CFA into the temporomandibular
joint (TMJ) (Fig. 3) elicited … ) immunoreactivity in the rat trigeminal ganglion before and 2 …